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In the world of pharmaceutical wonders, sildenafil is a noteworthy discovery that has revolutionized the intervention for erection difficulties. In the fight against sexual malfunction, Sildenafil is a constant, like a dependable knight who charges in when called upon and withdraws after the task at hand is completed. This blog will unravel the mysteries of Sildenafil’s length of the drug’s job, the optimal time for its administration, the moment to let its effects wane, and much more.
What is Sildenafil Citrate?
Sildenafil Citrate is a trusted ally in the realm of pharmaceuticals. It is a prescription remedy predominantly used to combat erectile dysfunction (ED)/impotence in men.
In the era of the 1980s, a flicker of hope emerged from the laboratories of Pfizer, a pharmaceutical titan. The compound, labeled Sildenafil Citrate, was the fruit of meticulous R&D, with its inception rooted in the year 1989.
The initial objective of this scientific endeavor was to fabricate a remedy for angina pectoris, a malady characterized by chest discomfort due to cardiac disease, and hypertension, a condition marked by elevated blood pressure. However, the journey led to the birth of Viagra. Around the 1980s the first synthesis took place in the sandwich laboratories owned by Pfizer that nestled in the womb of the United Kingdom.
As the heart clinical trials unfolded, a serendipitous discovery was made. The researchers found that the drug was more adept at provoking erections than alleviating angina. This revelation was nothing short of groundbreaking, as it unveiled a novel therapeutic domain for the compound.
How Sildenafil works?
Among a bunch of potent remedial therapies for impotence sildenafil and its generic versions like Cenforce 100 mg and Fildena 100 is the leading lead that has conquered the market. Although all these drugs function almost 90% in the same way, the things that differ are their lasting effects, dosage strengths, and potential flank effects. So let’s speak about sildenafil’s working method first;
To be clear-cut the central function of our dynamic drug is to deal with the amount of notorious PDE-5 enzyme present in the reproductive area. Because their quantity is the very reason that affects how men’s erections are induced. As long as they are in excessive amounts, erections become a work of trouble. They precisely need to be at moderate levels. However, if that’s not the case, erectile dysfunction is the case.
Here sildenafil comes to your erections retrieval. The drug controls the enzyme population which builds hurdles by narrowing down the blood passage to the reproductive area. By inhibiting the PDE-5 enzyme, sildenafil allows for increased blood flow, resulting in improved and sustained erections. This mechanism of action has proven to be highly effective in treating erectile dysfunction and restoring sexual confidence in men.
How Long Does Sildenafil Take To Work?
First off, it depends on how you have administered the dosage i.e, with meals or on an empty stomach. If the former is the case the drug should take somewhere between an hour or two to start activating and reach its maximum potency.
If the latter is the case, it might take 30 to 60 minutes only to cover the system. In short, the heavier you are the longer it will take to kick in. Moreover, the drug should disappear completely in a day, falling by 50% every three to five hours. The same is the case with generic alternatives of sildenafil i.e, Nizagara 100 and Cenforce 150.
How Long Does Sildenafil Typically Last?
Speaking of the lasting impacts of sildenafil, it generally lingers in the system for somewhere between 4 to 6 hours at full potency. However, that doesn’t imply that you will be out and about throughout that time sporting an erection. It’s just you will not have a hardship-inducing erection as long as you are sexually stimulated.
Furthermore, even after the specified point, you can still be able to get an erection. Everything is dependent on your sexual activity, age, health condition, and dose.
How Do Different Dosages Compare In Terms Of Their Effectiveness?
The effectiveness of Sildenafil is contingent on the quantity present in your body. Initiating treatment with a high dose can prolong its effects, but only to a certain extent. The highest recommended dosage is 100mg. However, exceeding this limit can lead to heart complications and a higher likelihood of adverse impacts.
If you administer a dose of 25mg, its effectiveness may last for only 2-3 hours. It depends on your body weight and the severity of broken erectile function. When you seek a prescription, only your medic or druggist can guide you on an appropriate starting dosage. Although for most men, the usual initial dose is 50mg.
Sildenafil Versus Other Erectile Dysfunction Treatments
Speaking of other remedial choices we have three more drugs that are used in substitution of sildenafil. Those drugs are Tadalafil, Vardenafil, and Avanafil. Unlike other mentioned drugs (including sildenafil) here Tadalafil is a bit different as it possesses the ability to give an ultimate erection for about 36 hours long. It holds the monopoly in the market of long-lasting erectile dysfunction treatments.
Vardenafil, on the other hand, is known for its fast onset of action and effectiveness in men with diabetes. Avanafil, the newest addition, boasts a rapid onset of action and a lower risk of side effects compared to sildenafil. However, you can’t decide for yourself which one will work better for you, it’s your physician’s job.