PDE5 Inhibitors: How They Work, Types & More

PDE5 Inhibitors: How They Work, Types & More

Well, terms like PDE5 inhibitors might be common and frequent sounds in the hospital wards and chambers. But these names are quite challenging for laymen to understand. That’s why this blog will act as a rescuer for all those damsels in distress (just kidding). Jokes apart, PDE5 inhibitors like Zenegra 100 Mg and Cenforce Soft have become closely integrated things in many of our lives. How?

Just like blood pressure and diabetes meds are taking over the world, the discussed drugs in the blog are next in the line. Since its usage is rampantly going over the roof, it has become an urgent need to understand every aspect concerned with it. So let’s get going with our blog piece.

What Are PDE5 Inhibitors?

Since we are discussing in depth these PDE5 blockers aka inhibitors, approaching its history seems like a good place to start. Knowing how these drugs have been developed and how they function, can be informative about why they are widely used in present-day society. 

It all starts with Henry Hyde Salter, a British physician who served his career in the 18s. He saw that the wheezing and breathing difficulties narrowed down in his chest and diminished after taking a steamy cup of coffee. Initially, he didn’t recognize that this relief was due to the bronchodilator effect of caffeine which of course is a non-selective but rather a weak PDE5 inhibitor. 

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However, slowly and gradually, the experimentation took place and paved the way for the development of robust PDE5 inhibitors. But this wasn’t easy, initially, these drugs were employed for addressing hypertension and angina. 

Surprisingly, rather than fixing those two issues the drug triggered erections in patients, hence, this insight transferred the attention to managing ED.

Read More>> How To Reverse Erectile Dysfunction?

What Are PDE5 Inhibitors Used To Treat?

Since the accidental discovery was fortunate for erectile dysfunction sufferers, the drugs were prepare to make available in the market for treating ED, which is now the primary aim. However, apart from fixing erections, these PDE 5 inhibitors have properties to heal or regulate the following conditions as well. Let’s see how it does that.

Erectile Dysfunction


There is an activity run by cGMP that facilitates the hard-ons by calming down the smooth muscles and widening the blood vessels in the genitals. However, the rise in the number of PDE 5 enzymes degrades the cGMP function, hence erections are not achieved or maintained properly.  

By taking PDE-5 inhibitors like Vilitra 20mg, Vilitra 60 Mg, or something similar the enzymes’ disturbances are controlled, and a good working environment for erections is facilitated. 

Pulmonary Hypertension

It is worth noting that PDE5 is also present in the smooth muscle layers of the lung arterioles. With regard to pulmonary hypertension, PDE5 inhibitors operate in such a way as to lead to a widening of the pulmonary arteries and a reduction in the systolic blood pressure within these structures. 

Benign Prostatic Hyperplasia

During this condition, the muscles in the genitals swell up which makes urination painful and uncomfortable. However, taking these drugs can soothe down the muscle and eliminate the complications including a burning feeling while urination. 

One more additional point to add is that these PDE 5 inhibitors are mix with SSRI to address premature ejaculation (PE) and ED at once. For instance, Super Fildena and Extra Super Tadarise.

4 Types To Know 

So far in the history of PDE 5 blockers only 4 drugs have developed that are FDA-approved. Although all of these possess almost similar characteristics, their popularity is largely based on individual preferences, tolerances, and many other such aspects. So let’s have a look at them separately. 


In the village of PDE 5 inhibitors, sildenafil can consider as a founding member because it is the very first drug ever introduce or develope in this domain. Although it was an accidental discovery, it surely fundamentally altered the management of erectile dysfunction. 

Moreover, it also made the scope for more development in the area which gave the space for the introduction of other similar drug components. Try generic Viagra like Cenforce 100 Blue Pill from Medicscales for affordable alternatives. 

Speaking of sildenafil citrate, the term Viagra is often use synonymously, as it is the brand name under which sildenafil is trade. The usual doses are somewhere between 25 to 100mg which can last for about 4 hours or 12 hours maximum in certain cases. 


It is market under the brand name Cialis, the same as sildenafil is sale under the name Viagra. Tadalafil, nicknamed the weekend pill, is a long-acting PDE type 5 inhibitor that received approval from the FDA in the year 2003.

It brings an opportunity for an erection of up to 36 hours per dose, which makes it an ideal option for men preferring the one-time tablet. The dose to use as needed is 10 mg; while daily-use Cialis ensures an “ever-ready” hard-on. 

Moreover, in present times, Cialis is not the first choice, people are rather choosing generic tadalafil for the same effectiveness but at much lesser cost. Check out popular generic tadalafil tablets like Cialis 60 Mg, Megalis 20mg, and many more from Medicscales.  


It might come as a surprise for many of you to know that there actually exists second-generation PDE 5 inhibitors as well. The first runner-up in this second-generation category is Avanafil

They act in a comparable manner to all other PDE5 agents though they possess selective action as well, which lessens the chances of negative effects. Presently marketed under the brand Stendra, the method brings a satisfying resolution to erectile dysfunction within a quarter of an hour. 

As with the majority of phosphodiesterase 5 inhibitors, it can result in vision matters; nevertheless, it isn’t as dangerous as the majority of other medications in this category.  


Vardenafil also goes by the name Levitra as per its brand identity. And it is consider the newest member of the generation. Vardenafil was born in the year 2003 with the aim of providing a more effective and efficient treatment plan for ED. 

Unlike Sildenafil, Vardenafil provides relief from the ED in a shorter amount of time with a longer period of effectiveness, i.e, 4 to 8 hours. Moreover, your food intake doesn’t interact at all with the dose. 

Just like the brand Levitra its generic counterparts like Valif 20mg and Alvitra 40 Mg act with the same efficiency in countering sexual dysfunction.

How Do PDE5 Inhibitors Work?

All these drugs have now become common PDE-5 inhibitors which is why its working mechanism has also become more widely understood. Still here is a brief breakdown of it. 

PDE5 inhibitors act by inhibiting the enzyme PDE5 that is in charge of catalyzing the breakdown of cGMP which is a molecule that is connect with nitric oxide and smooth muscle relaxation of blood vessels. 

These inhibitors also counteract the degradation of cGMP thus enabling the release of nitric oxide which results in proper dilation of blood vessels and an increase in blood flow to the penis regions. This aids the stretching of the corpora cavernosa thus creating a wider and rigid erection, due to enhanced dilatation of the penile arterioles.

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